Current Topics in Microbiology and Immunology

Boehm, Thomas; Takahama, Yousuke

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Details

Published by: Springer

Publication Date: 2013-11-19

Format: Hardcover

ISBN-13: 9783642402517

DOI: 10.1007/978-3-642-40252-4

Dimensions: 235cm x155cm

Pages: 132