Improved adaptation of food production, particularly in areas where climate variability is large, holds the key to improving food security for human populations. Increasing climate knowledge and improved prediction capabilities facilitate the development of relevant climate information and prediction products for applications in agriculture to reduce the negative impacts due to climate variations and to enhance planning activities based on the developing capacity of climate science. This book, based on an International Workshop held in Geneva in 2005, reviews the advances made so far in seasonal climate predictions and their applications for management and decision-making in agriculture and identifies the challenges to be addressed in the next 5 to 10 years to further enhance operational applications of climate predictions in agriculture, especially in the developing countries.