Agricultural fungicides and pharmaceutical antifungals unified in one reference

Industry consolidation through mergers and corporate divestitures has complicated the information flow between agrochemical fungicide and pharmaceutical antifungal research, limiting cross-disciplinary innovation. Fungicides and Antifungals: Antimycotics in Agriculture and Medicine reconnects these two domains by presenting the most important antimycotic compound classes from both crop protection and medicine in a single, structured volume designed to accelerate the discovery of novel agents.

Each chapter follows a consistent format covering all important products and their discovery, mode of action, spectrum of activity, resistance issues, synthesis, structure-activity relationships, and analogs. The book treats four principal antifungal classes — azoles, echinocandins, polyenes, and allylamines — alongside three major fungicidal classes: DMIs, strobilurins, and SDHIs.

Readers will also find:

• An introductory chapter comparing key characteristics that distinguish antifungal drug development from agrochemical fungicide research
• Historical context tracing the parallel evolution of agricultural fungicides and pharmaceutical antifungals from early discoveries to current commercial products
• Comparative analysis of discovery strategies used across agrochemical and pharmaceutical research to identify effective antimycotic compounds
• Presentation of the four most important oomycetes-selective fungicide classes
• A dedicated chapter on very recent fungicides and antifungals with a novel mode of action

Organic chemists, agricultural scientists, biochemists, and life scientists working in academia or at agrochemical and pharmaceutical companies will find this volume directly applicable to their antimycotic research. It is also a targeted resource for university institute libraries and governmental authorities involved in crop protection or public health.

Clemens Lamberth is a retired senior principal scientist from the chemical research department of Syngenta Crop Protection AG in Switzerland, where he specialized in fungicide discovery for more than 30 years. He is the inventor of the fungicide mandipropamid and the author of more than 110 peer-reviewed publications and book chapters, and 135 patents. He (co-)edited the three Wiley-VCH books "Bioactive Heterocyclic Compound Classes", "Bioactive Carboxylic Compound Classes", and the 4^th edition of "Modern Crop Protection Compounds". He also serves on the editorial board of the international journal "Pest Management Science". In 2018, he received the Senior Industrial Science Award from the Swiss Chemical Society.