The 121 revised full papers presented were carefully reviewed and selected from 163 submissions. They are organized in the following topical sections: smart manufacturing system characterization; product and asset life cycle management in smart factories of industry 4.0; cyber-physical (IIoT) technology deployments in smart manufacturing systems; multi-disciplinary collaboration in the development of smart product-service solutions; sustainable human integration in cyber-physical systems: the operator 4.0; intelligent diagnostics and maintenance solutions; operations planning, scheduling and control; supply chain design; production management in food supply chains; factory planning; industrial and other services; operations management in engineer-to-order manufacturing; gamification of complex systems design development; lean and green manufacturing; and eco-efficiency in manufacturing operations.