This volume constitutes the proceedings of Third Pan-African Conference on Artificial Intelligence, PanAfriCon AI 2025, held in Addis Ababa, Ethiopia, during November 20–21, 2025.

The 18 full papers presented were thoroughly reviewed and selected from 93 submissions. They are organized in the following topical sections: Natural Language Processing and LargeLanguage Models; Data Analysis; Cyber Security; Medical and Biological AI; Robotics; AI in Engineering.