This volume constitutes the proceedings of the 6th International Conference on Smart Applications and Data Analysis, SADASC 2026, held in Marrakech, Morocco, in January 29-31 2026.

The 33 full papers and 14 short papers presented together with 4 Keynotes were carefully reviewed and selected from 105 submissions. They cover the following topics: Smart Applications & Systems 1; Green, Sustainable Computing 1; IoT & Cyber-Physical Technologies 1; Smart Applications & Systems 1; Advances in Cybersecurity and Threat Mitigation; AI & Machine Learning 2; Green, Sustainable Computing 2; IoT & Cyber-Physical Technologies 2; Smart Applications & Systems 2; AI & Machine Learning 3.