This book constitutes the refereed proceedings of the 45th International Conference on Computer Safety, Reliability, and Security, SAFECOMP 2026, held in Valencia, Spain, during September 22–25, 2026.

The 23 full papers included in this volume were carefully reviewed and selected from 125 submissions. The papers cover the following topical sections: Fault tolerance and diagnosis; Safety Protection; Cybersecurity and mixed-criticality in safety-critical systems; Safety of AI-Based Systems; Industrial Safety Engineering in the AI-Era; Engineering Safety Systems; Practice of hazard analysis and risk assessment; Quantitative methods; Real-time aspects; and Testing.