This book provides state-of-the-art information on logistics and implementation of Lean Healthcare models, and showcases what industrial engineering and medical science can offer together to increase the value of patient-oriented healthcare in the next scenario 5.0. It covers a wide range of topics such as artificial intelligence models oriented to 5.0 healthcare sustainability, agile models and lean methods in healthcare, risk management models focused on healthcare systems, engineering of healthcare systems requirement, ontology and cognitive models on healthcare engineering, project management methods applied to healthcare innovation, medical informatics and bioinformatics, software methods and applications for biomedicine, emergency management models. The book gathers the refereed proceedings of the 2nd International Conference Logistics & Lean Engineering for Advanced Healthcare Methodologies Modelling (LLEAHMM), held in Naples, Italy, on October 14-17, 2025.