This book is a compilation of different research contributions, all relating to the application of Artificial Intelligence (AI) in Smart Infrastructures. The included chapters deal with new opportunities and challenges presented by emerging technologies in healthcare, cybersecurity, smart infrastructure, sustainable energy, and intelligent automation. Each included chapter provides a detailed description of either a prototype, case study, project or solution developed by researchers. In addition, this book provides in-depth explanations of how the state-of-the-art technologies are being integrated into real-world applications through the use of advanced computational models. The overall objective of this book is to provide researchers and practitioners with a compilation of conceptual and practical applications in the areas of multimodal learning, explainable AI, hybrid optimization framework, predictive analytics, and autonomous systems.