This book serves as a valuable guide for clinicians seeking to deliver impactful interventions aimed at modifying the pain conditions of their patients. Pain is a complex multifactorial condition, while allodynia is led by biological changes induced in the peripheral and central nervous system that can be reverted by having the proper knowledge to assess and treat it.

Untreated and persistent neuropathic pain can lead patients into a state of chronicity due to the slow natural recovery of the peripheral nerves and to the generally high intensity pain experience, impacting also on the psychological level leading to mood changes like anxiety and depression. Studies show that the pharmacological strategies to treat this condition have little to null long term effect. Untreated allodynia can manifest in various ways depending on the affected area and the associated biological changes. Sometimes neuropathic pain is a direct consequence of a tissue damage like an injury or a surgical procedure. But in most cases, there is a lack of linear correspondence between long lasting pain an injury detectable by the patient inspection and clinicl assessment .

This book guides physiotherapists step by step in setting the proper assesment and work diagnosis and planning a hands-on treatment strategy. Based on the latest research, it demonstrates how to facilitate the physiological healing process with scientific proven effects for pain recovery and functional gain to restitutio ad integrum, when this is possible.

Claudia Carta BSc. MA 2011 Bachelor in Health and Sciences:

Physiotherapy, university of applied sciences FH Joanneum Graz 2016 Master of Arts, Applied Ethics; Karl Franzens University Graz 2022 Assistant Teacher for Vojta-Principle of neurodevelopmental treatments

Dr. Giacomo Carta earned his Ph.D. in Experimental Medicine and Therapy from the University of Turin in 2022. His doctoral research focused on in-depth studies of neuropathic pain and peripheral nerve regeneration. His professional traineeship in physiotherapy was oriented to neurological rehabilitation and rehabilitation of chronic and acute musculoskeletal pain syndromes. He had many important experiences in many of the most important hospitals in Milan, with two soccer teams in the B league, with professional ballet dancers and sport-climbers.

Currently he is serving as a Postdoc Researcher at the Systems Biology of Pain Laboratory within the Division of Pharmacology & Toxicology at the University of Vienna, Austria. His main ongoing studies involve the assessment of pain modulation and gut microbiota changes due to mechanical vagus nerve non-invasive stimulation. He also studies neuropathic pain processes related to scar tissue drug-resistant pain after mastectomy, and the impact of pain chronicity mediators and neuropathic pain signs in non-specific shoulder pain patients. Since 2008 he is a clinical tutor for the Bachelor's degree in Physiotherapy at the University of Milan, and since 2018 also for the University of Turin for the Master of Science degree in Rehabilitation science.

He is a respected member of scientific and professional societies, including the International Association for the Study of Pain (IASP) and the Società Italiana di Riabilitazione Neurologica (SIRN).

Dr. Carta has authored numerous scientific papers and has been an invited speaker at various

international congresses in the fields of Pain and Rehabilitation Medicine, Physiotherapy, and Neuromorphology. His contributions have been recognized with prestigious awards, including the "Young Investigator Award" at the National Congress of the Italian Society of Experimental Biology and the

National Congress of the Italian Society of Neuromorphology