This book explores the applications of third space endoscopy - an innovative application of traditional endoscopy that facilitates surgical tissue removal, intentional scar formation, or muscle division in a minimally invasive and incisionless fashion.

The main topics presented include tissue removal, such as endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), endoscopic full-thickness resection (EFTR) and peroral tumorectomy (POET); intentional scar formation, such as anti-reflux mucosectomy (ARMs) and transoral incisionless fundoplication (TIF); and muscle division, such as peroral endoscopic myotomy (POEM) of the cricopharyngeus (ZPOEM) and pylorus (G-POEM). Despite their existence for years, many of these applications are underutilized and perhaps under-recognized by the greater medical community. Additionally, third space endoscopy spans the entire body and is performed across numerous specialties, therefore creating a single resource that encompasses all the applications in-depth will be a powerful and convenient tool for practitioners.

Third Space Endoscopy is an excellent resource for medical students, residents, fellows, and attending physicians in both the surgical and gastroenterological disciplines.

Michael Ujiki, MD, Department of Minimally Invasive Surgery, NorthShore University Health System, Evanston, IL, USA

Zachary M. Callahan, MD, The University of Tennessee Health Science Center - Nashville Campus, Nashville, TN, USA