This volume constitutes the refereed post-conference proceedings of the 6th International Conference on Machine Learning and Intelligent Communications, MLICOM 2021, held in November 2021. Due to COVID-19 pandemic the conference was held virtually.

The 28 revised full papers were carefully selected from 58 submissions. The papers are organized thematically in tracks as follows: internet of vehicle communication system; applications of neural network and deep learning; intelligent massive MIMO communications; intelligent positioning and navigation systems; intelligent space and terrestrial integrated networks; machine learning algorithms and intelligent networks; image information processing.