This book constitutes the thoroughly refereed proceedings of the 10th EAI International Conference on e-Infrastructure and e-Services for Developing Countries, AFRICOMM 2018, held in Dakar, Senegal, in November 2018. The 28 full papers were carefully selected from 49 submissions. The accepted papers provide a wide range of research topics including e-health, environment, cloud, VPN and overlays, networks, services, e-Learning, agriculture, IoT, social media, mobile communication and security.