This book provides an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. Informative and cutting-edge, the volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. The book is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology. The authors offer a broad overview of the field. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches. The final sections of the volume provide ideas for theoretical and modeling optimization in systemic biological researches, presenting most algorithms as implementations, including an up-to-date full range of bioinformatic programs and available successful applications.