This book provides an up-to-date summary of the principles of protein evolution and discusses both the methods available to analyze the evolutionary history of proteins as well as those for predicting their structure-function relationships.

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• Includes a significantly expanded chapter on genome evolution to cover genomes of model organisms sequenced since the completion of the first edition, and organelle genome evolution
  
• Retains its reader-friendly, accessible style and organization
  
• Contains an updated glossary and new references, including a list of online reference sites

Laszlo Patthy is the head of the Extracellular Proteolysis Group of the Institute of Enzymology, Budapest. In the last twenty-five years the main area of his experimental research has been the molecular biology, structure, function, and evolution of multidomain protein components of extracellular proteolytic systems of vertebrates. He is the author of Protein Evolution by Exon-shuffling (1995) and Protein Evolution (Blackwell, 1999).