Targeting bacterial efflux pumps and secretion systems to combat resistance

Antimicrobial resistance driven by bacterial efflux pumps and secretion systems demands integrated molecular and therapeutic understanding. Bacterial Efflux Pumps and Secretion Systems: Molecular Mechanisms, Challenges, and Inhibitors, 2 Volume Set provides a detailed examination of these two mechanisms, covering their molecular architecture, functional dynamics, roles in biofilm formation and chronic infections, and strategies for therapeutic targeting across pathogenic bacteria.

Volume One addresses the structural and functional diversity of all major efflux pump families, their contributions to multidrug resistance, and inhibition strategies using natural products, omics technologies, and computational approaches. Volume Two examines the six major secretion systems, T1SS through T6SS, detailing their molecular mechanisms, virulence contributions, interplay with efflux systems, and next-generation inhibitor development targeting secretion-mediated pathogenesis.

Key topics also include:

• Biofilm-associated chronic infection mechanisms and how efflux pumps and secretion systems cooperate to sustain resistant bacterial communities
• Computational drug design approaches for identifying and developing novel efflux pump inhibitors with restored antimicrobial efficacy against pathogens
• Translational clinical strategies connecting molecular-level bacterial defense mechanisms with actionable therapeutic interventions for infectious disease management
• Natural product-based antimicrobial discovery pipelines targeting quorum sensing regulatory networks and biofilm-associated infections in resistant organisms
• Integrated coverage linking basic microbiology research with pharmaceutical and public health applications across both clinical and laboratory settings

Designed for academic researchers in microbiology, molecular biology, and infectious diseases, as well as clinical microbiologists, pharmaceutical professionals, and graduate scholars, this two-volume reference connects molecular mechanisms with translational clinical approaches to address antimicrobial resistance as a critical global health challenge.

Siddhardha Busi is an Associate Professor in the Department of Microbiology, Pondicherry University, India. His research focuses on bacterial quorum sensing, biofilms, antimicrobial photodynamic therapy, and nanobiotechnology, with over 15 years of research experience and 14 years of university-level teaching.

Subhaswaraj Pattnaik, PhD is an Assistant Professor in Zoology, Govt. Women’s College, Sambalpur University, India. He has over nine years of research experience in antimicrobial drug discovery, anti-biofilm strategies, microbial pathogenesis, and therapeutic management of urinary tract infections in ESKAPE pathogens.

Ramjee Prasad, PhD is an Associate Professor at the Department of Botany, Mahatma Gandhi Central University, India. A recipient of the Sir CV Raman Scientist Award and Global Best Scientist Award, he has over 300 publications and 15 years of teaching and research experience.