Neuroinflammation and Autophagy in Neurodegeneration: Mechanistic Insights into Cellular Biology and Advanced Multimodal Therapeutics

Khanal, Pukar; Patil, B. M.; Chikhale, Rupesh

This book explores the complex interplay between neuroinflammation and autophagy, offering a comprehensive understanding of how these processes drive the development and progression of neurodegenerative diseases. It establishes how chronic inflammation not only disrupts autophagy but also creates feedback loops that exacerbate cellular dysfunction and accelerate neurodegeneration.

The book’s core focus is on presenting biological processes at the cellular level, such as neuronal function, glial activation, and protein aggregation in multiple metabolic brain diseases. It discusses key pathways such as mTOR, AMPK, and inflammasomes that directly affect neuronal function. It contains dedicated chapters on Alzheimer’s, Parkinson’s, ALS, Huntington’s, and Multiple Sclerosis, offering disease-specific insights and tailored discussions for each condition. The book complements these mechanistic insights with therapeutic strategies, lifestyle interventions, and emerging trends in biomarkers and personalized medicine. It highlights emerging treatments, repurposed anti-inflammatory drugs, and the neuroprotective property of diet and microbiome. Thus, this book establishes a multidisciplinary perspective combining insights from neuroscience, molecular biology, immunology, and pathology to provide a well-rounded understanding of neurodegenerative mechanisms and therapies. 

The emphasis on dual-pathway modulation and the holistic perspective in the book makes it an essential resource for researchers, clinicians, and healthcare professionals in neurology and neurobiology who seek a comprehensive understanding of neurodegenerative disease mechanisms. Graduate and advanced undergraduate students in neuroscience will also benefit from the detailed exploration of cellular pathways and therapeutic strategies.

Details

Published by: Springer

Publication Date: 2025-11-22

Format: Hardcover

ISBN-13: 9789819539444

DOI: 10.1007/978-981-95-3945-1

Dimensions: 235.0cm x155.0cm

Pages: 287.0