This two-volume set, constitutes the revised selected papers of the 16th International Symposium on Intelligence Computation and Applications, ISICA 2025, held in Guangzhou, China, during November 15-16, 2025.

The 63 full papers included in these proceedings were carefully reviewed and selected from178 submissions. They were organized in the following topical sections: 

Part I : Frontiers of Evolutionary Intelligent Optimization Algorithms; Intelligent Systems and Detection Technology.
Part II : Exploration of Computer Vision; Machine Learning and Its Applications; AI Empowering Education and Design Innovation.