This book constitutes the refereed proceedings of the Second International Conference on Artificial Intelligence Computing and Systems, AICompS 2025, which took place in Fukuoka, Japan, in November 26–28, 2025.

The 30 full papers and 10 short papers were included in this book were carefully reviewed and selected from 69 submissions. This conference focused on a broad range of topics spanning artificial intelligence, AI privacy and safety, secure and trustworthy AI systems, as well as systems, networks, hardware, and information security for AI-driven environments.