{"product_id":"9789813366152","title":"Springer Theses: Methodology and Applications","description":"\u003ch1\u003eSpringer Theses: Methodology and Applications\u003c\/h1\u003e \u003ch2\u003eHu, Kuan\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. \u003cbr\u003e\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2022-01-27\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9789813366152\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-981-33-6613-8\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 102\u003c\/p\u003e ","brand":"Springer Nature Singapore","offers":[{"title":"Default Title","offer_id":45582791639180,"sku":"9789813366152","price":179.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9789813366152.jpg?v=1779568606","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9789813366152","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}