Learning Materials in Biosciences: About Modeling, Computation, and Circuit Design

Marchisio, Mario Andrea

The textbook is based on the lectures of the course “Synthetic Biology” for Master’s students in biology and biotechnology at the Harbin Institute of Technology. The goal of the textbook is to explain how to make mathematical models of synthetic gene circuits that will, later on, drive the circuit implementation in the lab. Concepts such as kinetics, circuit dynamics and equilibria, stochastic and deterministic simulations, parameter analysis and optimization are presented. At the end of the textbook, a chapter contains a description of structural motifs (e.g. positive and negative feedback loops, Boolean gates) that carry out specific functions and can be combined into larger networks. Moreover, several chapters show how to build up (an analyse, where possible) models for synthetic gene circuits with four different open-source software i.e. COPASI, XPPAUT, BioNetGeN, and Parts & Pools-ProMoT.

Details

Published by: Springer

Publication Date: 2018-05-24

Format: Paperback

ISBN-13: 9789811087516

DOI: 10.1007/978-981-10-8752-3

Dimensions: 240cm x168cm

Pages: 187