{"product_id":"9789401063432","title":"Medical Science Symposia Series: Risk Reduction Strategies","description":"\u003ch1\u003eMedical Science Symposia Series: Risk Reduction Strategies\u003c\/h1\u003e \u003ch2\u003ePaoletti, Rodolfo; Crosignani, P.G.; Kenemans, P.; Samsioe, G.; Soma, Maurizio; Jackson, Ann S.\u003c\/h2\u003e \u003cp\u003eDespite its universality in human female aging, the menopause  and its biology are not completely understood. New biologic mechanisms  by which sex hormones may be detrimental or confer protection are  continually being discovered. \u003cbr\u003e  We are now starting to understand that the role of the estrogen  receptor is not identical in all tissues. Important nongenomic effects  for sex hormones have also been described. Hormone replacement therapy  (HRT) has produced effects on health risks: some are reduced, some are  increased, and the rest remain uncertain. HRT is being used by an  increasing number of women to alleviate climacteric symptoms in the  perimenopausal period and to prevent osteoporosis and cardiovascular  disease later. Positive effects on Alzheimer's disease and dementia on  the one hand, and an increase in venous thrombosis on the other, are  currently being reported by several groups. Both the preventive  benefits and the risk of breast cancer seem to be linked to long-term  and current use. HRT requires further testing through specific  clinical trials, currently underway in the United States, before  confident recommendations may be made about the full range of benefits  and risks.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-10-28\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9789401063432\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-011-5560-1\u003c\/p\u003e \u003cp\u003eDimensions: 240cm x160cm\u003c\/p\u003e \u003cp\u003ePages: 341\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":44358431670412,"sku":"9789401063432","price":49.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9789401063432.jpg?v=1776454053","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9789401063432","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}