{"product_id":"9789401058391","title":"Medical Science Symposia Series: From Basic Science to Clinical Application","description":"\u003ch1\u003eMedical Science Symposia Series: From Basic Science to Clinical Application\u003c\/h1\u003e \u003ch2\u003ePaoletti, Rodolfo; Jackson, Ann S.; Poli, A.\u003c\/h2\u003e \u003cp\u003eThis volume, based on the International Congress \u003cem\u003eCreatine:  From\u003c\/em\u003e \u003cem\u003eBasic Science to Clinical Application\u003c\/em\u003e, held in Milan on  June 4, 1999, outlines the physiological role of creatine in the human  body as well as its possible role in different pathological  conditions. Creatine is already used as a dietary supplement to  augment muscle performance in healthy individuals and inpatients with  immobilizing diseases, such as complex fractures. There is also an  increasing interest in its administration in a growing number of  clinical conditions. A specific deficit of endogenous synthesis of  creatine which responds to high dosage exogenous supplementation has  been described. In cardiac failure and in chronic obstructive  pulmonary disease, creatine improves the contractility of the muscular  system. Promising effects of this substance have also been described  in animal models of neurodegenerative disorders, such as amyotrophic  lateral sclerosis, and in some mitochondrial cytopathies. \u003cbr\u003e  This volume is of obvious interest to basic scientists working on the  physiology of creatine and to clinicians interested in its medical  indications.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-11-05\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9789401058391\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-011-4237-3\u003c\/p\u003e \u003cp\u003eDimensions: 240cm x160cm\u003c\/p\u003e \u003cp\u003ePages: 120\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":45580703826060,"sku":"9789401058391","price":49.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9789401058391.jpg?v=1775754716","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9789401058391","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}