{"product_id":"9789401057875","title":"Myasthenia Gravis: Disease Mechanism and Immunointervention","description":"\u003ch1\u003eMyasthenia Gravis: Disease Mechanism and Immunointervention\u003c\/h1\u003e \u003ch2\u003eChristadoss, Premkumar\u003c\/h2\u003e \u003cp\u003eAutoimmune myasthenia gravis (MG) is a classical autoimmune  disease, for which the target antigen, nicotinic acetylcholine  receptor, has been cloned, sequenced and biochemically characterized.  Antibodies to acetylcholine receptors destroy acetylcholine receptor  at the neuromuscular junction, thus leading to defective neuromuscular  transmission, muscle fatigue, and weakness. \u003cbr\u003e  In the last few years, rapid advances have been made in unraveling the  cellular and molecular mechanisms involved in the pathogenesis of MG,  both in the animal model, experimental autoimmune MG (EAMG), and in  human MG. Significant advances are being made in characterizing the  cells and molecules involved in the autoimmune response to the  acetylcholine receptor (AChR). These advances are leading to the  development of specific methods of immunointervention in EAMG. Further  understanding of the intricate involvement of the major  histocompatibility complex (MHC) and non-MHC genes, T cell receptors  (TCR), costimulator molecules, and specific cytokines in the afferent  and efferent autoimmune response of AChR should pave the way to future  antigen\/clone-specific therapy of MG. \u003cbr\u003e  This book is the outcome of the MG workshop proceedings in Mysore,  India, 1998. The majority of the chapters in this book are contributed  by world-renowned authors and their students. The book not only  contains a timely review of specific topics, but also up-to-date  findings. Immunologists and neurologists will find, in this volume,  the latest in MG\/EAMG cutting-edge research. Clinicians will be  interested in the applications of the various immunointervention  strategies into clinical trials in MG patients. Finally, students will  not only be interested in reading the latest in EAMG\/MG research, but  will also find information to help them develop a future strategy to  unravel the precise mechanism of disease. \u003cbr\u003e  To summarize, in this book, the readers should find up-to-date  information related to immunological mechanisms involved in MG  pathogenesis and various modalities for possible approaches to  immunointervention to treat MG.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-11-06\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003e ISBN-10: 9789401057875\u003c\/p\u003e \u003cp\u003eISBN-13: 9789401057875\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-011-4060-7\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 208\u003c\/p\u003e ","brand":"Springer","offers":[{"title":"Default Title","offer_id":44358697025676,"sku":"9789401057875","price":99.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9789401057875.jpg?v=1755111977","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9789401057875","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}