{"product_id":"9789401048392","title":"Developments in Cardiovascular Medicine: Role of the Endothelium","description":"\u003ch1\u003eDevelopments in Cardiovascular Medicine: Role of the Endothelium\u003c\/h1\u003e \u003ch2\u003evan Gilst, W. H. (Wiek); Lie, K.J.\u003c\/h2\u003e \u003cp\u003eDuring the last decade we have witnessed a rapid expansion of  our knowledge of the role of the endothelium in the control of  vascular tone and hemostasis. In paricular, developments in molecular  biology have enabled us to understand its physiology in greater  detail. Furthermore, it is now clear that dysfunction of the  endothelium contributes to various cardiovascular diseases. This is  especially true for the coronary vascular bed. Development of  atherosclerosis, disturbed vasomotor tone in stable ischemic  syndromes, and the interaction of thrombocytes with the endothelium in  acute ischemic syndrome are all consequences of endothelium  dysfunction. Also, secondary changes in endothelial function have been  described, for instance in chronic heart failure. This monograph  reviews the present knowledge of the role of the endothelium in the  control of coronary flow. The authors lead the reader through this  topic starting at the basic physiology of endothelial function and the  principles of coronary flow regulation. Next, the use of modern  clinical techniques to evaluate endothelial function such as positron  emission tomography and angioscopy are discussed. Subsequently,  several pathophysiological processes and the role of endothelium are  addressed. Finally, the interaction of various presently used  cardiovascular drugs with the endothelium is indicated. It is the  combination of basic sciences with clinical observations in this book  which may be appreciated by a large number of scientists and  physicians active in the field of cardiovascular disease. It is also  this combination of different disciplines which will determine future  developments and new avenues in pharmacotherapy  involving the  endothelium.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-10-04\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9789401048392\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-011-1900-9\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 150\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":46311876067468,"sku":"9789401048392","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9789401048392.jpg?v=1771513672","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9789401048392","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}