{"product_id":"9789400960350","title":"Developments in Cardiovascular Medicine","description":"\u003ch1\u003eDevelopments in Cardiovascular Medicine\u003c\/h1\u003e \u003ch2\u003eGodfraind, T.; Herman, A.G.; Wellens, D.\u003c\/h2\u003e \u003cp\u003e2 The free internal Ca+ concentration in human red cells is set according to the leak­ 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca­ 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady­ 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con­ 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec­ 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra­ tion is ;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower).\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2011-11-04\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9789400960350\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-94-009-6033-6\u003c\/p\u003e \u003cp\u003eDimensions: 244cm x156cm\u003c\/p\u003e \u003cp\u003ePages: 325\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":47378659442828,"sku":"9789400960350","price":49.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9789400960350.jpg?v=1775710358","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9789400960350","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}