Diet and Cancer

Srivastava, Sanjay K.

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Details

Published by: Springer

Publication Date: 2013-05-07

Format: Hardcover

ISBN-13: 9789400763166

DOI: 10.1007/978-94-007-6317-3

Dimensions: 235cm x155cm

Pages: 178