Structure-based Drug Discovery

Jhoti, Harren; Leach, Andrew R.

Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.

The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.

Details

Published by: Springer

Publication Date: 2010-10-19

Format: Paperback

ISBN-13: 9789048171231

DOI: 10.1007/1-4020-4407-0

Dimensions: 235cm x155cm

Pages: 250