{"product_id":"9789048171101","title":"RAS Family GTPases","description":"\u003ch1\u003eRAS Family GTPases\u003c\/h1\u003e \u003ch2\u003eDer, Channing\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eSince 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons.\u003c\/p\u003e\n\u003cp\u003eFirst, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large superfamily of Ras-related small GTPases. Over 150 Ras-related small GTPases are found in the human genome, with orthologs found in all vertebrate species and invertebrates.\u003c\/p\u003e\n\u003cp\u003eThis book features chapters by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2010-10-28\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9789048171101\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/1-4020-4708-8\u003c\/p\u003e \u003cp\u003eDimensions: 240.0cm x160.0cm\u003c\/p\u003e \u003cp\u003ePages: 397.0\u003c\/p\u003e ","brand":"Springer Netherlands","offers":[{"title":"Default Title","offer_id":44541632938124,"sku":"9789048171101","price":206.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9789048171101.jpg?v=1759288417","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9789048171101","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}