{"product_id":"9783764362553","title":"Milestones in Drug Therapy","description":"\u003ch1\u003eMilestones in Drug Therapy\u003c\/h1\u003e \u003ch2\u003eDunzendorfer, Udo\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003eThis drug is a landmark discovery, which consequently has become the definitive therapy for the treatment of erectile dysfunction (ED). Following the major breakthrough in the field of nitric oxide (NO)-physiology and pharmacology leading to sildenafil being marketed, the most current information is presented in this reference book, including ongoing research from several disparate groups about NO as endothelium-derived relaxing factor (EDRF) and also as a neurotransmitter for nerves innervating erectile tissue in mammals.\u003c\/p\u003e\n\u003cp\u003eThe development of sildenafil as an oral phosphodiesterase-5 (PDE5) inhibitor drug for the treatment of ED resulted in one of the first products, which made its way successfully from basic NO research to routine clinical therapy.\u003c\/p\u003e\n\u003cp\u003eThis volume addresses all fields of sildenafil application in both men and women. In a highly competitive research environment with a critical medical need for drug improvements the reader will learn more about clinical resistance to sildenafil treatment and the modalities to overcome the failure rates. \u003c\/p\u003e\n\u003cp\u003eThe individual chapters cover clinical use, pharmacokinetics, pharmacodynamics, biochemistry, and cultural aspects. They are written by leading experts in their respective fields. Therefore, readers – whether professionals in the pharmaceutical industry, physicians treating ED, biochemists, chemists or pharmacologists – will find a detailed and up-to-date knowledge base about current research activities and an excellent overview for further research on this compound class and its cultural impact.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Birkhäuser\u003c\/p\u003e \u003cp\u003ePublication Date: 2004-10-25\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783764362553\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-0348-7945-3\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 202\u003c\/p\u003e ","brand":"Birkhäuser Basel","offers":[{"title":"Default Title","offer_id":50088424112268,"sku":"9783764362553","price":224.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783764362553.jpg?v=1779501936","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783764362553","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}