Metronomic Chemotherapy: Pharmacology and Clinical Applications

Bocci, Guido; Francia, Giulio

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Details

Published by: Springer

Publication Date: 2014-09-26

Format: Hardcover

ISBN-13: 9783662436035

DOI: 10.1007/978-3-662-43604-2

Dimensions: 235cm x155cm

Pages: 295