Current Topics in Microbiology and Immunology

Fillatreau, Simon; O'Garra, Anne

This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.

Details

Published by: Springer

Publication Date: 2014-07-28

Format: Hardcover

ISBN-13: 9783662434918

DOI: 10.1007/978-3-662-43492-5

Dimensions: 235cm x155cm

Pages: 238