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Peters, Sven Erik

Enantioselective metallaelectro-catalyzed C─H activation represents an innovative strategy for enabling the transition of organic synthesis to a more resource-economic mode of operation. It circumvents substrate prefunctionalization by directly exploiting otherwise inert C─H bonds to construct complex three-dimensional scaffolds from simple molecular building blocks. Furthermore, the mild electrocatalytic conditions evade chemical oxidants, while producing molecular hydrogen as the sole by-product, enabling the connection of organic synthesis to a possible future decentralized green hydrogen economy.
Still, disclosed methodologies predominantly rely on noble metal catalysts. Examples using earth-abundant 3d transition metals remain scarce despite the substantially improved ecological and economic implications and diminished toxicity. This work addresses this shortcoming by investigating the first enantioselective nickelaelectro-catalyzed C─H activation and various cobaltaelectro-catalyzed conversions. On this occasion, the synthetic versatility is examined and various mechanistic experiments are presented for fostering future developments.

Details

Published by: Springer Spektrum

Publication Date: 2025-02-22

Format: Paperback

ISBN-13: 9783658471095

DOI: 10.1007/978-3-658-47110-1

Dimensions: 210cm x148cm

Pages: 96