BestMasters: ODE Constrained Mixture Modeling and Approximate Bayesian Computation

Loos, Carolin

Carolin Loos introduces two novel approaches for the analysis of single-cell data. Both approaches can be used to study cellular heterogeneity and therefore advance a holistic understanding of biological processes. The first method, ODE constrained mixture modeling, enables the identification of subpopulation structures and sources of variability in single-cell snapshot data. The second method estimates parameters of single-cell time-lapse data using approximate Bayesian computation and is able to exploit the temporal cross-correlation of the data as well as lineage information. 

Details

Published by: Springer Spektrum

Publication Date: 2016-03-23

Format: Paperback

ISBN-13: 9783658132330

DOI: 10.1007/978-3-658-13234-7

Dimensions: 210cm x148cm

Pages: 92