{"product_id":"9783642816833","title":"Chemotherapy and Radiotherapy of Gastrointestinal Tumors","description":"\u003ch1\u003eChemotherapy and Radiotherapy of Gastrointestinal Tumors\u003c\/h1\u003e \u003ch2\u003eKlein, H.O.\u003c\/h2\u003e \u003cp\u003eAttempts to influence survival of patients with colorectal cancer (CRC) by adjuvant chemotherapy are limited by the variability of survival in different prognostic groups [4] and the paucity of drugs that have shown activity in the advanced disease [10]. Of the few drugs which are active in the advanced disease, only 5-fluorouracil (5-FU) and razoxane «±1,2-bis(3,4-dioxopiperazin-1-yl)propane) are suitable for long-term adjuvant treatment [2, 9]. 5-FU has been widely and intensively studied as adjuvant chemotherapy in CRC [7], but there is no unanimity that it has even the marginal influence on survival that has been claimed [3, 10]. Razoxane has not previously been tested for adjuvant or maintenance treatment in CRC. It has however a number of biological activities which might be thought useful in the treatment of residual or minimal tumours [1] and which might therefore make it useful as an adjuvant. Thus it specifically prevents tumour dissemination and metastases in some tumours and normalizes the neovasculature which the tumours induce [6, 8, 11]. The drug is not cytotoxic in the usual sense, does not affect non-dividing cells, and only blocks cell division during a brief period of the cell cycle in late G and\/or early mitosis [12]. It does so non-selectively and most cells capable of 2 division examined so far have been affected by the drug. Even affected cells however are not destroyed immediately, but may increase in size and become multinucleate [5].\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2011-12-21\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783642816833\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-642-81681-9\u003c\/p\u003e \u003cp\u003eDimensions: 244.0cm x170.0cm\u003c\/p\u003e \u003cp\u003ePages: 112.0\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":44450524233868,"sku":"9783642816833","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783642816833.jpg?v=1768311916","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783642816833","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}