{"product_id":"9783642799129","title":"Current Topics in Microbiology and Immunology: The E2F Gene Family","description":"\u003ch1\u003eCurrent Topics in Microbiology and Immunology: The E2F Gene Family\u003c\/h1\u003e \u003ch2\u003eFarnham, Peggy J.\u003c\/h2\u003e \u003cp\u003eIt is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through­ out the lifespan of all animals. An important control point in this balance occurs in the G, phase of the cell cycle. On the basis of environmental cues a cell in G, must decide whether to continue through the proliferative cycle and enter S phase (where DNA replication occurs) or to exit from the proliferative cycle into a nonreplicating state. Alterations in the mechanisms that nor­ mally control this decision can lead to cancer, cell death, or loss of differentiated cellular phenotypes. The identification of the E2F gene family of transcription factors has allowed a more complete understanding of how the cell maintains an appropri­ ate proliferative state. This volume provides an up-to-date ac­ count of present reports concerning E2F as well as a framework for future investigations. E2F activity requires heterodimerization of two partners. Either partner can be one of several different transcription factors; E2Fl, E2F2, E2F3, E2F4, or E2F5 can heterodimerize with either DPl or DP2. Cellular promoters whose E2F sites mediate a link between transcription and proliferation drive genes whose products are required for DNA synthesis and genes that encode regulators of cell growth. A detailed analY$is of the role that E2F family members play in transcription from these promoters is presented in the chapter by J. E. SLANSKY and P. J. FARNHAM.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2011-12-14\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783642799129\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-642-79910-5\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 141\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":44358952616076,"sku":"9783642799129","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783642799129.jpg?v=1776431831","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783642799129","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}