{"product_id":"9783642680717","title":"Current Topics in Microbiology and Immunology","description":"\u003ch1\u003eCurrent Topics in Microbiology and Immunology\u003c\/h1\u003e \u003ch2\u003eHaller, O.\u003c\/h2\u003e \u003cp\u003eNatural resistance is now coming to be recognized as a potentially important phenomenon in host defense against infection and ma­ lignancy. Genetically controlled resistance mechanisms are usUally effective early in infection and before conventional immune responses are generated. Comparisons of experimental systems where natural resistance plays a prominent role demon­ strate the complexities of the host defense mechanisms involved, as evidenced in the present volume. Nevertheless, some com­ mon components of genetic resistance are discernible and largely comprise natural killer cells, macrophages, and interferon These and additional factors would seem to constitute a first line of de­ fense in host resistance against both viruses and tumors. It is evi­ dent that considerable variation in the relative importance of di­ stinct mechanisms may be found among various resistance sy­ stems and that, most likely, additional effector functions will be discovered. Resistance to tumors and most viruses is under polygenic control, has a complex mode of inheritance, and depends on appro­ priately complex effector mechanisms. Instances, however, whe­ re a single gene locus determines resistance or susceptibility to a virus, as in the case of resistance to flaviviruses or influenza viru­ ses, would seem to offer good prospects for elucidating the basic factors involved. Resistance to influenza virus would indeed seem to represent a comparatively simple situation: resistance is expressed at the host cell level, and interferon is its main media­ tor. The present volume provides insight into current concepts of such resistance mechanisms.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-01-09\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783642680717\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-642-68069-4\u003c\/p\u003e \u003cp\u003eDimensions: 244cm x170cm\u003c\/p\u003e \u003cp\u003ePages: 130\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":44450454864012,"sku":"9783642680717","price":49.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783642680717.jpg?v=1775707165","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783642680717","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}