{"product_id":"9783642267017","title":"Springer Theses: Synthesis of Nitrogen-Containing Polycyclic Compounds","description":"\u003ch1\u003eSpringer Theses: Synthesis of Nitrogen-Containing Polycyclic Compounds\u003c\/h1\u003e \u003ch2\u003eOhta, Yusuke\u003c\/h2\u003e \u003cp\u003eA copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure.  This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2013-02-25\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783642267017\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-642-15473-7\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 104\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":47392796016780,"sku":"9783642267017","price":49.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783642267017.jpg?v=1775767853","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783642267017","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}