{"product_id":"9783642246319","title":"Springer Theses: Synthesis and Biological Evaluation","description":"\u003ch1\u003eSpringer Theses: Synthesis and Biological Evaluation\u003c\/h1\u003e \u003ch2\u003eDuffy, Colm\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eIn this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation. \u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-01-05\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783642246319\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-642-24632-6\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 130\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":47392665141388,"sku":"9783642246319","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783642246319.jpg?v=1775767810","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783642246319","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}