{"product_id":"9783642066047","title":"Protein Folding Kinetics: Biophysical Methods","description":"\u003ch1\u003eProtein Folding Kinetics: Biophysical Methods\u003c\/h1\u003e \u003ch2\u003eNölting, Bengt\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eProtein Folding Kinetics - Biophysical Methods (2nd Edition) gives a deep insight into the principles and concepts of the kinetic and structural resolution of fast chemical and biophysical reactions of proteins with emphasis on protein-folding reactions. The study of fast protein-folding reactions and the understanding of the folding paradox have significantly advanced due to the recent development of new biophysical methods which allow not only kinetic resolution in the sub-millisecond time scale but also structural resolution with unprecedented precision. Pathways and structures of early and late folding events and the transition state structures of fast- and ultrafast-folding proteins can now be studied in far more detail. Important techniques include biophysical, chemical, molecular biological and mathematical methods, in particular protein engineering, Phi-value analysis, time-resolved circular dichroism, optical triggers and pulsed infrared LASER methods, pressure and temperature jump, ultrafast mixing, stopped flow and quenched flow, dielectric relaxation and electric-field-jump, acoustic relaxation, fluorescence- and isotope-labeling, H\/D exchange methods, NMR line broadening and stopped-flow NMR, transition state theory, solutions of rate equations, and evolutionary computer programming. Protein Folding Kinetics - Biophysical Methods is written for students and researchers in biochemistry, biophysics, and related fields. \u003c\/p\u003e\n\u003cp\u003eSpecial features in the second edition: \u003c\/p\u003e\n\u003cp\u003e-Includes detailed information and 12 color figures on the high resolution of folding transition states.\u003c\/p\u003e\n\u003cp\u003e-Discusses structural determinants of the rate of protein folding on a timescale from microseconds to seconds.\u003c\/p\u003e\n\u003cp\u003e-Provides information on self-evolving computer programs for protein-folding simulations and protein-structure predictions.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2010-02-12\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783642066047\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/b138868\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 222\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":49472220201100,"sku":"9783642066047","price":125.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783642066047.jpg?v=1777988346","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783642066047","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}