{"product_id":"9783540672913","title":"Current Topics in Microbiology and Immunology","description":"\u003ch1\u003eCurrent Topics in Microbiology and Immunology\u003c\/h1\u003e \u003ch2\u003eAktories, K.; Wilkins, T.D.\u003c\/h2\u003e \u003cp\u003e\u003ci\u003eClostridium difficile\u003c\/i\u003e has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of \u003ci\u003eClostridium difficile\u003c\/i\u003e and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to \u003ci\u003eClostridium difficile\u003c\/i\u003e toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. \u003ci\u003eClostridium difficile\u003c\/i\u003e toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2000-07-06\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783540672913\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-662-06272-2\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 150\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":50089756491916,"sku":"9783540672913","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783540672913.jpg?v=1779502859","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783540672913","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}