{"product_id":"9783540594956","title":"Clinical Pharmacology in the Elderly: Reference Ranges and Biological Variations After Repeated Measurements","description":"\u003ch1\u003eClinical Pharmacology in the Elderly: Reference Ranges and Biological Variations After Repeated Measurements\u003c\/h1\u003e \u003ch2\u003eHeine, P.R.; Breuel, Hans-Peter; Kuhlmann, J.; Horkulak, J.; Weyer, G.\u003c\/h2\u003e \u003cp\u003eThe appropriate and rational use of drugs by the elderly is a matter of growing medical and social concern. Persons aged 65 years and older constitute about 12%-15% of the population in the Western world, and the total number of the elderly will increase significantly in the coming years. This population accounts for 30% of all the prescription drugs used. Aging, specifically the transition from middle to old age, is a complex process. From the perspective of clinical pharmacology, these pathophysiological changes may reasonably be expected to alter responsiveness to drugs. The age-related differences in response to drugs can arise from alterations in pharmacokinetics or pharmacodynamics. This makes it mandatory that clinical pharma­ cological studies be carried out in the elderly during extended phase I studies. The older the population likely to use the drug, the more important it is to include the very old. It is also important not to exclude .... :''lecessarily patients with concomitant illnesses; it is only by observing, such patients that drug-disease interactions can be detected. Reports from surveillance systems have greatly increased our awareness of problems associated with drug therapy in old age.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1995-12-01\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783540594956\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-642-60998-5\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 182\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":44358621954188,"sku":"9783540594956","price":49.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783540594956.jpg?v=1775786427","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783540594956","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}