{"product_id":"9783540572398","title":"Dupuytren’s Disease: Pathobiochemistry and Clinical Management","description":"\u003ch1\u003eDupuytren’s Disease: Pathobiochemistry and Clinical Management\u003c\/h1\u003e \u003ch2\u003eBerger, Alfred; Delbrück, Axel; Brenner, Peter; Hinzmann, Rolf\u003c\/h2\u003e \u003cp\u003eIn this volume a distinguished group of internationally\nrenowned clinicians and basic researchers discuss the\npresent state of knowledge of the etiologyand pathogenesis\nof Dupuytren's contracture, a disease responsible for      a\nconsiderable portion of disabilities within the working\npopulation allover the world. Although the riddle of how\nthe contracture of the palmar    fascia develops is still\nunsolved, the data on the pathobiochemistry and    clinic of\nDupuytren's Disease achieved in recent years has led to           a\nbetter understanding of the biochemical and morphological\nprocesses   underlying the deformation and malfunction of the\nafflicted tissues.        Research in Dupuytren's Disease now\nenters the era of molecular medicine,   which opens up new\nexperimental means of studying the pathological          changes\nwhich occur during the formation of the contracture on              a\nmolecular level. In particular, data are presented as to the\nrole of  specific biological macromolecules influencing the\nphenotype expression of  the palmar fascia cells which are\ninvolved in autoimmune reactions and      present both at the\ncell surface as well as in the extracellular matrix     to\nregulate cell-to-cell and cell-to-matrix interactions. In\nvitro cell culture models to investigate fibro-cytic\nmodulations are available and havebeen applied to study the\neffects of specific biological molecules on       isolated cells\nfrom healthy palmar fascia and Dupuytren's                   contracture.\nComplementary evaluations of morphological,                    epidemiological,\nand clinical data contribute essentially to the            present\nunderstanding of the etiology and pathogenesis of\nDupuytren's   Disease. This comprehensive and informative\nsummary of the state of the art is completed by numerous\nreferences affixed to the individual contributions.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1994-03-18\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783540572398\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-642-78517-7\u003c\/p\u003e \u003cp\u003eDimensions: 235.0cm x155.0cm\u003c\/p\u003e \u003cp\u003ePages: 301.0\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":44541779542156,"sku":"9783540572398","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783540572398.jpg?v=1759295060","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783540572398","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}