Comprehensive introduction to the design principles, response mechanisms, and imaging applications of organic small-molecule fluorescence probes

Fluorescent Probes for Bioactive Species provides a systematic primer for organic small-molecule fluorescence probes. The book starts by discussing the principles of molecular recognition, the phenomenon of fluorescence luminescence, and fluorescent probes design. Each chapter of the book is separated based on the classification of biologically active species. Instead of gathering all of the related fluorescent probes for a typical analyte, the book mainly focuses on the representative probes that present new recognition mechanisms and the related optimization theories to realize better detection and imaging.

In each chapter, the relationship and differences between the complex biomolecules of the species are discussed. The corresponding pros and cons of the recognition mechanisms based on these structural or reactive differences create the core of each section’s discussion. Finally, the specifics of biological sample-oriented design and development of fluorescent probes are discussed.

Fluorescent Probes for Bioactive Species includes information on:

• Excitation modes of fluorescent probes, fluorescence reporting modes, and optical modulation mechanisms of fluorescent probes
• Fluorescent probes of hydrogen peroxide (H2O2), hypochlorous acid (HCiO), hydroxyl radical (OH), superoxide anion (O&ndash2), and singlet oxygen (1O2)
• Synthesis, recognition mechanism, and bioimaging of norepinephrine probes, dopamine probes, acetylcholine probes, glutamic acid, 5-hydroxytryptamine, and histamine
• Active molecules and enzymes of dual-responsive fluorescent probes
• Biological functions of reactive sulfur species (RSS)

Fluorescent Probes for Bioactive Species is an essential, up-to-date reference for chemists, scientists, and professionals in the sensor industry seeking to promote the development of new tools for biomonitoring and develop a deep understanding of mysterious biological events.

Professor Caixia Yin is a Director of the Key Laboratory of Chemical Biology and Molecular Engineering at the Ministry of Education and Institute of Molecular Science, Shanxi University, China. She received the Outstanding Young Scholar award from the National Natural Science Foundation of China for and was selected as the 2022 Elsevier China Highly Cited Scholar, the 2022 the World's Top 2% Top Scientists (Lifetime Lists), and the 2020 Chinese Chemical Letters Outstanding Young Scholar.