{"product_id":"9783527351008","title":"RNA as a Drug Target The Next Frontier for Medicinal Chemistry","description":"\u003ch3\u003eMethods \u0026amp; Principles in Medicinal Chemistry\u003c\/h3\u003e\u003ch1\u003eRNA as a Drug Target\u003c\/h1\u003e\u003ch2\u003eThe Next Frontier for Medicinal Chemistry\u003c\/h2\u003e\u003ch3\u003eJohn Schneekloth | Martin Pettersson | Raimund Mannhold | Helmut Buschmann | Jörg Holenz\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Pharmacology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cb\u003eDiscover a new paradigm in drug discovery that greatly expands the space of addressable drug targets and potential novel drugs\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eExisting paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids have emerged as a viable focus for target-based drug discovery, with the potential to revolutionize the strategy and approach for this essential step in the drug development process.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eRNA as a Drug Target: The Next Frontier for Medicinal Chemistry \u003c\/i\u003eoffers a practice-oriented introduction to developing drug-like small molecules that selectively modulate both coding and non-coding RNAs. Beginning with a description and characterization of existing druggable RNAs, the book discusses how to approach different RNA targets for drug discovery. The result is a crucial resource for targeting RNAs and creating the next generation of life-saving pharmaceuticals.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eRNA as a Drug Target \u003c\/i\u003ereaders will also find:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eA complete “toolbox” for working with RNA, from structure determination to screening and lead generation techniques\u003c\/li\u003e \u003cli\u003eA wide range of addressable targets and mechanisms, including splicing modulation, riboswitches, targeted degradation, and more\u003c\/li\u003e \u003cli\u003eAuthoritative discussion of the potential of RNA-targeted small molecule therapeutics for drugging the epitranscriptome\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eRNA as a Drug Target\u003c\/i\u003e provides an expert introduction to a new frontier in pharmaceutical research for medicinal chemists, biochemists, molecular biologists, and members of the pharmaceutical industry.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e \u003cp\u003e\u003cb\u003eJohn Schneekloth, Jr., PhD (Jay),\u003c\/b\u003e obtained his PhD from the chemistry department of Yale University. Following postdoctoral work at Princeton, Dr. Schneekloth joined the NCI, where his research involves using synthetic chemistry and high throughput chemical biology approaches to develop chemical probes of RNA, with a particular emphasis on targeting RNA with druglike small molecules.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMartin Pettersson, PhD,\u003c\/b\u003e obtained his PhD in Organic Chemistry from the University of Texas at Austin. He is a medical chemistry \/ drug discovery leader with over 20 years of industrial experience, mainly with Pfizer (co-inventor of Paxlovid). He has then continued as Senior Director of Neuroscience\/Pain, Chemistry, at Grünenthal Boston Innovation Hub, and most recently as VP of Drug Discovery at Promedigen in South Korea.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e31 December 2024\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley-VCH\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9783527351008\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e416\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e24.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44380483092620,"sku":"9783527351008","price":178.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783527351008.jpg?v=1780617785","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783527351008","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}