{"product_id":"9783527350131","title":"Inducing Targeted Protein Degradation From Chemical Biology to Drug Discovery and Clinical Applications","description":"\u003ch1\u003eInducing Targeted Protein Degradation\u003c\/h1\u003e\u003ch2\u003eFrom Chemical Biology to Drug Discovery and Clinical Applications\u003c\/h2\u003e\u003ch3\u003ePhilipp Cromm\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Pharmacology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cb\u003eInducing Targeted Protein Degradation\u003c\/b\u003e \u003cp\u003e\u003cb\u003eEnables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003eSince the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. \u003ci\u003eInducing Targeted Protein Degradation\u003c\/i\u003e is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space.  \u003c\/p\u003e\n\u003cp\u003eIn \u003ci\u003eInducing Targeted Protein Degradation\u003c\/i\u003e, readers will find the most recent information on:  \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCellular mechanisms of targeted protein degradation and current approaches \tto utilize these mechanisms for drug discovery \u003c\/li\u003e \u003cli\u003eA comparison of different induced degradation approaches, including PROTAC, molecular glues, LYTACs and ATTECs as well as additional post translational modifications\u003c\/li\u003e \u003cli\u003eDrug development aspects such as DMPK optimization and criteria for the selection of clinical candidates\u003c\/li\u003e \u003cli\u003eA discussion of the potential of targeted degradation for expanding the druggable space\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e  \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eInducing Targeted Protein Degradation\u003c\/i\u003e will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e \u003cp\u003e\u003cb\u003ePhilipp Cromm\u003c\/b\u003e studied Chemistry at the Technical University Munich where he worked in the group of Horst Kessler. For his master's thesis he spent time with David J. Craik at the Institute for Molecular Bioscience and received his PhD under guidance of Herbert Waldmann at the Max-Planck-Institute for Molecular Physiology. Thereafter, he carried out postdoctoral studies in the group of Craig Crews at Yale University working on targeted protein degradation. In 2018 Philipp joined Bayer AG as a Medicinal Chemist.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e22 November 2022\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley-VCH\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9783527350131\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e384\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e31.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44311015227532,"sku":"9783527350131","price":167.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783527350131_a03f5e3a-40e8-464c-8a14-69aa3a552e4d.jpg?v=1780617638","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783527350131","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}