{"product_id":"9783527323319","title":"Methods \u0026 Principles in Medicinal Chemistry: Identification and Optimization of Drug-like Molecules","description":"\u003ch1\u003eMethods \u0026amp; Principles in Medicinal Chemistry: Identification and Optimization of Drug-like Molecules\u003c\/h1\u003e \u003ch2\u003eFaller, Bernard; Urban, Laszlo; Mannhold, Raimund; Kubinyi, Hugo; Folkers, Gerd\u003c\/h2\u003e \u003cp\u003eThe only reference on current methods to generate pharmacokinetic and safety profiles of drug candidates, as well as how they must be balanced against one other for the best selection of candidates for further development.\u003cbr\u003e Following a brief introduction to the necessities of filtering and risk assessment of potential new drug molecules before actual drug development, the two equally important aspects of pharmacological (ADME) and safety (toxicity) profiling are covered in separate parts.\u003cbr\u003e The ADME section covers the profiling of basic physicochemical parameters, such as solubility and permeability, as well as more complex traits, such as the likelihood of drug-drug interactions, metabolic clearance and protein binding properties.\u003cbr\u003e The toxicology part addresses, among others, recent advances in early genetic toxicity testing, bioactivation screening, organ-specific toxicity assays for liver, heart, kidney and blood, as well as profiling for autoimmune reactions.\u003cbr\u003e By addressing both drug efficiency and drug safety, this modern practical reference shows readers how each individual aspect figures in shaping the key decisions on which the entire drug development process hinges. In short, this is a complete toolbox for assessing the risk\/benefit ratio for any novel compound during the early drug development stages, using both in vitro and in silico methods.\u003cbr\u003e Both editors are based at one of the leading research-driven pharmaceutical companies, and the authors have been recruited from numerous other global players in the field.\u003cbr\u003e Invaluable know-how for every medicinal chemist and drug developer.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Wiley-VCH\u003c\/p\u003e \u003cp\u003ePublication Date: 2009-10-05\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783527323319\u003c\/p\u003e \u003cp\u003eDOI: \u003c\/p\u003e \u003cp\u003eDimensions: 246.40cm x177.80cm\u003c\/p\u003e \u003cp\u003ePages: 533\u003c\/p\u003e ","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44377704267916,"sku":"9783527323319","price":238.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783527323319.jpg?v=1775666068","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783527323319","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}