Methods & Principles in Medicinal Chemistry

Causes and Remedies for Attrition and Withdrawal

Contributors: Langer, Thierry; Bryant, Sharon D.; Mannhold, Raimund; Kubinyi, Hugo; Folkers, Gerd

While it is well known that 99.9 % of drug candidates never reach the market, the reasons for this enormous failure rate are often obscure. Everyone working in drug discovery or development is faced with this struggle, and learning from past failures is nowhere more important than in the drugs industry.
Here, insiders share their professional insight on issues that have hardly been covered in other publications. In the past, failed attempts have often received less attention than they deserved, allowing many common mistakes to be repeated. By drawing attention to common risks and pitfalls, the authors enable readers to significantly improve their own success rates.
The topics are not only addressed on the theoretical level, but are also illustrated by case studies of real-life drugs, some of which -- Viagra, Vioxx, Lipobay -- are well-known from the business headlines.
A must-read for professionals in the pharmaceutical industry.

Book Details

• Publisher: Wiley-VCH
• Publication Date: 2016-01-12
• Format: Hardcover
• ISBN-13: 9783527318797
• Pages: 280