{"product_id":"9783319996639","title":"Escherichia coli, a Versatile Pathogen","description":"\u003ch1\u003eEscherichia coli, a Versatile Pathogen\u003c\/h1\u003e \u003ch2\u003eFrankel, Gad; Ron, Eliora Z\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cdiv\u003e\n\u003cp\u003e\u003ci\u003eEscherichia coli \u003c\/i\u003eis a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized \u003ci\u003eE. coli\u003c\/i\u003e clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. \u003ci\u003eE. coli\u003c\/i\u003e pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, \u003ci\u003eE. coli\u003c\/i\u003e infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal \u003ci\u003eE. coli\u003c\/i\u003e (e.g. \u003ci\u003eE. coli\u003c\/i\u003e O104) or extraintestinal pathogenic strains (e.g. \u003ci\u003eE. coli\u003c\/i\u003e ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targetsand development of vaccines that offer lasting protection.\u003c\/p\u003e\n\n\u003cp\u003eThis volume focuses on several types of \u003ci\u003eE. coli \u003c\/i\u003einfections (intestinal and extraintestinal), virulence factors, and \u003ci\u003eE. coli\u003c\/i\u003e pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of \u003ci\u003eE. coli\u003c\/i\u003e, and in related vaccine development.\u003c\/p\u003e\n\u003cbr\u003e\n\u003c\/div\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2018-11-13\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783319996639\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-319-99664-6\u003c\/p\u003e \u003cp\u003eDimensions: 235.0cm x155.0cm\u003c\/p\u003e \u003cp\u003ePages: 242.0\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":45378847735948,"sku":"9783319996639","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319996639_e03f3f8b-31df-464a-88a4-1bdfbeea9eab.jpg?v=1765469797","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783319996639","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}