{"product_id":"9783319865027","title":"Current Topics in Microbiology and Immunology","description":"\u003ch1\u003eCurrent Topics in Microbiology and Immunology\u003c\/h1\u003e \u003ch2\u003eBarth, Holger\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of \u003ci\u003eClostridium botulinum\u003c\/i\u003e neurotoxins, \u003ci\u003eClostridium botulinum\u003c\/i\u003e C3 toxin, \u003ci\u003eClostridium difficile\u003c\/i\u003e toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding\/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2018-08-30\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783319865027\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-319-58893-3\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 256\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":46265505579148,"sku":"9783319865027","price":161.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319865027.jpg?v=1770781364","url":"https:\/\/fh90cf-fv.myshopify.com\/products\/9783319865027","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}